Serine proteases affecting blood coagulation and fibrinolysis from snake venoms.
نویسنده
چکیده
Snake venom proteases, in addition to their contribution to the digestion of the prey, affect various physiological functions. They affect platelet aggregation, blood coagulation, fibrinolysis, complement system, blood pressure and nervous system. This review provides a ready reference for serine proteases that interfere in blood coagulation and fibrinolysis. They exhibit their activity by activation of specific zymogens of coagulation factors. These serine proteases serve as tools to study molecular details in the activation of specific factors involved in coagulation and fibrinolytic cascades and are useful in treating various thrombotic and hemostatic conditions.
منابع مشابه
[Snake venom Kunitz/BPTI family: Structure, classification and pharmacological potential].
Snake venoms are rich sources of serine proteinase inhibitors that are members of the KunitzBPTI (bovine pancreatic trypsin inhibitor) family. Generally, these inhibitors are formed by 60 amino acids approximately. Their folding is characterised by a canonical loop that binds in a complementary manner to the active site of serine protease. Some variants from snake venoms show only weak inhibito...
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عنوان ژورنال:
- Pathophysiology of haemostasis and thrombosis
دوره 34 4-5 شماره
صفحات -
تاریخ انتشار 2005